While restructuring is increasingly acknowledged as an inherent characteristic of economic development and receives substantial policy attention at European and Member State level, the regional perspective on it is rarely discussed. However, most large-scale restructurings affect the regions and employment areas where they take place, not just the company and its employees. Based on secondary data analysis, a literature review and five in-depth case studies, this research project aims to identify the effects of large-scale restructuring at regional level. It also describes examples of successful regional management directed at maintaining and improving labour markets and living conditions following an important restructuring event. The case studies created under this research project are available on demand from Eurofound. Requests should be directed to Irene Mandl, Research Manager, firstname.lastname@example.org. An executive summary is also available - see Related content.